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Structural Biology 2019: Nrf2, the key transcription factor that regulates the cellular response to oxidative stress, is intrinsically disordered- Nadun Chanaka Karunatilleke- The University of Western Ontario

Abstract

Nadun Chanaka Karunatilleke1, Courtney Fast2, Vy Ngo3, Anne Brickenden1, Martin Duennwald3, Lars Konermann1,2, Wing-Yiu Choy1

Receptive oxygen and nitrogen species (ROS, RNS) are continually produced in the body from interior digestion and outside introduction. In ordinary cells, responsive oxidants are created in a controlled way and some fill helpful needs. Oxidants shaped in light of physiological prompts go about as significant flagging particles to direct such procedures as cell division, aggravation, insusceptible capacity, autophagy, and stress reaction. Uncontrolled creation of oxidants brings about oxidative pressure that impedes cell capacities and adds to the improvement of malignancy, incessant illness, and poisonousness (2–5). From prokaryotes to people, responsive oxidants apparently work as significant controllers of both physiological and pathophysiological results.