メタボリックシンドロームジャーナル

Metabolic Syndrome: A Comprehensive Review on Understanding Pathophysiology, Clinical Implications and Different Management Strategies

Abstract

Usha Devi and Suman Kapila*

Metabolic syndrome, a multifaceted cluster of conditions encompassing insulin resistance, central obesity, dyslipidemia, and inflammation, poses a significant global health challenge. This comprehensive review synthesizes current knowledge on the pathophysiology, clinical implications, and management strategies associated with metabolic syndrome. In exploring the intricate interplay of insulin resistance, obesity-related inflammation, and hormonal factors, we elucidate the mechanisms underlying this syndrome. Clinical implications delve into the heightened risks of cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver disease, and renal dysfunction, emphasizing the syndrome's profound impact on morbidity and mortality. The review critically examines lifestyle modifications, pharmacological interventions, and weight management strategies, underscoring their pivotal roles in mitigating metabolic syndrome. Additionally, we highlight the importance of regular monitoring and patient education in fostering sustained self-management. Current research advancements and emerging therapies are discussed, providing insights into the evolving landscape of metabolic syndrome management. Challenges and future directions underscore the complexities of addressing this syndrome and propose avenues for further investigation. This review aims to consolidate existing knowledge, inform healthcare practices, and stimulate ongoing research to enhance our understanding and management of metabolic syndrome in the pursuit of improved public health outcomes.