皮膚科および皮膚科疾患ジャーナル

Lack of Association between Catalase Gene Polymorphism and Susceptibility to Vitiligo in an Egyptian Population

Abstract

Abdel-Khalek Hassan Younes, Essam- Eldin Mohammed, khaled Mohammed Tawfik, Hosny Badrawy Hamed, Shady Mahmoud Attia and Mohamed L Elsaie

Background: Vitiligo is an acquired hypomelanotic skin disorder resulting from the loss of functional melanocytes from the cutaneous epidermis. Low catalase (CAT) activity and accumulation of hydrogen peroxide (H2O2) have been demonstrated in the epidermis of vitiligo patients. Some polymorphisms on catalase gene may have effect on the quantity and activity of catalase enzyme. The aim of this study was to investigate whether catalase (CAT) gene polymorphisms are associated with susceptibility to vitiligo in Egyptian population. Materials and methods: Thirty patients with vitiligo and twenty gender, age and ethnic matched controls were enrolled in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The CAT gene -89A>T and 389C>T genotypes and allele frequencies of vitiligo patients did not differ significantly from those of healthy controls. Conclusions: We found no association between CAT gene -89A>T and 389C>T polymorphism and vitiligo susceptibility in Egyptian vitiligo patients. Further studies with greater sample size should be performed to verify these results.