Nooshin Bagherani, Serena Gianfaldoni and Bruce Smoller
Melasma is a common pigmentary skin disorder, characterized by symmetrically-distributed hyperpigmented patches with serrated, irregular and geographic borders. It usually affects the chronically photo-exposed cutaneous areas, especially the face and neck. Its exact worldwide prevalence is unknown. The disease most commonly occurs in women of reproductive ages. The etio-pathogenesis of melasma is not completely understood. This disorder seems to be an interplay of various internal and environmental factors. Among these factors, genetic predisposition, sunexposure and hormonal factors are the most important ones. In this article, in addition to the introduction of melasma, we have tried to review the most effective medications and modalities for the treatment of this common, refractory, pigmentary disorder.
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