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皮膚科および皮膚科疾患ジャーナル

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Aging Skin: Pathophysiology and Cutting-Edge Treatments

Abstract

Shoubing Zhang

The fight against aging, which is defined as a set of physiological mechanisms that alter the physical and intellectual capacities of humans, is one of the major challenges of the 21st century. This process includes more than just skin aging. Major healing defects are linked in part to changes in the biomechanical properties of skin cells, primarily dermal fibroblasts, that are associated with this condition. The immune system, which is also crucial for wound healing and maintaining skin homeostasis, is affected by time as well:Skin immunosenescence would result, promoting a pro-tumor environment while limiting the anti-infectious and vaccine responses. Before listing the effective anti-aging strategies to combat age-related dermal and epidermal stigmas, the primary skin damages caused by aging— whether intrinsic or extrinsic—will be discussed in detail.

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