Eugene Neyfakh, Aigule Alimbekova and Igor Suskov
Children and their mothers affected by the Chernobyl catastrophy suffer with toxic lipoperoxic stress coupled with hypovitaminoses A and E. The relation of these primary biochemical disturbances to notorious somatic consequences on mutagenic and teratogenic levels caused by chronic low-dose radiation of children from radiopolluted regions had been investigated. Rational approaches to prevent or to treat indicated pathologies were developed either. Vitamins A and E blood levels for newborns from radio polluted regions were near a third of normal ones. Simultaneous increasing of lipo-peroxidation for studied children had tendency to correlate with their body stigmation. Radiogenic indices of mutagenicity and teratogenicity showed dramatic increases along with fall of the essential antioxidants. The peroral poly vitamin therapy of women at the beginning of 1st trimester pregnancy prevented or corrected evaluated abnormalities for their newborns. Vitamin-protected children had normal ranges for studied indices. The combination of radiogenic biochemical deviations is supposed to be the primary molecular mechanisms for children restorable somatic hyper mutations and irreversible body stigmations but preventable by essential antioxidants via their mothers at early pregnancy.
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