Hassan W, Gul S, Rehman S, Noreen H, Shah Z, Mohammadzai I and Zaman B
Medicinal plants are an important source of bioactive compounds which can be used for the treatment of various diseases. The aim of the present study was to explore the phytochemical content and biological evaluation of Carum copticum essential oil and crude extracts. Antimicrobial activity of Carum copticum against six gram negative bacteria, three gram positive bacteria and one fungal strain were estimated. Furthermore, metallic content (Cr, Fe, Mn, Ni, Mg Zn, Cu and Ca), nutrient content and identification of the biologically active constituents were also evaluated. GC-MS characterization showed that p-cyme-3-ol (38.00%), o-cymene (37.44%), gamma-terpines (21.07%) and beta-pinene (1.42%) were present as major constituents. Antimicrobial activity of essentials oil was significant as compared with crude extract and exhibited maximum activity against B. atrophaeus (43 mm). The phytochemical screening confirmed the presence of terpenoids, steroids, flavonoids, alkaloids glycosides and reducing sugar. Metallic screening displayed the highest Ca (191.67 mg/l) concentration followed by Mg (52.275 mg/l), Fe (1.610 mg/l) and Mn (0.941 mg/l). The results obtained exposed that Carum copticum may be a significant source with interesting antimicrobial action and health protective potential.
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