肝臓学と膵臓科学

The mucosal loss is the critical mechanism of esophageal stricture after mucosal resection: A pilot experiment in a Porcine Model

Abstract

Bingrong Liu

Background and Aim: Esophageal stricture may be a major complication of huge area endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD). To date, the critical mechanism of esophageal stricture has not been fully elucidated. Here, we designed this experiment to explore the role of mucosal loss in esophageal stricture after mucosal resection during a porcine model. Material and Methods: Twelve swine were used for this study and randomly divided into two groups. Firstly, altogether the swine, two submucosal tunnels were made from 5 cm long and 1/3rd in breadth on the anterior and posterior wall of the esophageal circumference. After that, the covered mucosa was resected along the lateral edges of the tunnel within the group 1. The meanwhile covered mucosa was incised on the midline of the tunnels within the group 2. The process of stricture formation was evaluated by endoscopy after one, two and 4 weeks respectively. Anatomical and histological examinations were performed after euthanasia.