Shrestha PK, Basukala P, Yadav BK, Baral S and Sayami M
Background: South East Asia with its developing countries is a megacenter for Type 2 Diabetes Mellitus (T2DM) which is one of the biggest hurdles in its economic growth. Combating T2DM needs a better approach in an event of its diagnosis to reduce its future exorbitant complications.
Methods: We carried out this study to determine insulin resistance (IR) and beta-cell function using Homeostatic Model Assessment (HOMA) in T2DM at diagnosis. We also analyzed which routinely investigated parameters at diagnosis of T2DM had the strongest association to predict IR as accurately as HOMA2IR, for cost saving clinical use by the treating physicians.
Results: Among the 60 newly diagnosed T2DM patients, 43 were insulin resistant and 17 were non-insulin resistant. Waist-Hip ratio (WHR) and LDL-C/HDL-C ratio together predicted IR most accurately with a cut-off of 2.49. Waist circumference, BMI, visceral adiposity indicators, and TyG index could not predict IR on their own.
Conclusion: IR should be identified with affordable surrogates and offset with targeted anti-IR treatment right from the initial diagnosis of T2DM.
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