感染症と医学ジャーナル

Role of Probiotics in Preventing Antibiotic-Associated Diarrhea and Clostridium Difficile Infection

Abstract

Shuangbao Gun

Antibiotic-associated diarrhea (AAD) and Clostridium difficile infection (CDI) are common complications of antibiotic therapy. Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Several strains of probiotics have been studied for their effectiveness in preventing AAD and CDI, including Lactobacillus acidophilus, Bifidobacterium bifidum, and Saccharomyces boulardii. Studies have shown that probiotics can reduce the incidence of AAD by up to 60% and reduce the risk of CDI by up to 50%. While probiotics are generally safe and well-tolerated, healthcare providers should be aware of the potential risks and limitations associated with their use. Future research is needed to optimize the use of probiotics in the prevention of AAD and CDI, including determining the most effective strains and dosages, identifying patient subgroups that may benefit the most from probiotics, and exploring potential interactions between probiotics and antibiotics.