生薬学および天然物ジャーナル

In vitro Antibacterial Activity of Himalayan Lichenized Fungi

Abstract

Vinod Kumar, Manish Tripathi, Chandra Shekhar Mathela and Yogesh Joshi

The increase in the new strains of multi drug-resistant pathogens, the standard drugs have become less effective, thereby increasing the demand for the search of novel natural bioactive compounds from lichenized fungi. Despite rich diversity of lichenized fungi in Kumaon Himalaya, only a few of them have been screened for their biological activities. Present communication deals with antimicrobial activity of ethyl acetate extracts of Everniastrum cirrhatum, Usnea longissima, Flavoparmelia caperata and Ramalina conduplicans against five pathogenic bacteria. Among these, U. longissima and F. caperata extracts have revealed significant activity against all the bacteria while U. longissima was more active against Escherichia coli (13.0 mm; MIC=7.5 mg/mL) and Bacillus subtilis (11.6 mm; MIC=7.5 mg/mL). The F. caperata extract was active against E. coli (15.3 mm; MIC=15 mg/mL). Hence, there is an interest in the potential uses of antibiotics derived from lichenized fungi for pharmaceutical purposes.