Kobporn Sukphopetch
From 2018 to 2020, the Chikungunya virus (CHIKV) outbreak re-emerged in Thailand with a report of greater than 10,000 instances up till the give up of 2020. Here, we studied acute CHIKV-infected sufferers who had introduced to the Bangkok Hospital for Tropical Diseases from 2019 to 2020 by using assessing the relationship between viral load, scientific features, and serological profile. The outcomes from our find out about confirmed that viral load was once notably excessive in sufferers with fever, headache, and arthritis. We additionally decided the neutralizing antibody titer in response to the viral load in patients, and our facts aid the proof that an advantageous neutralizing antibody response in opposition to the virus is necessary for manipulate of the viral load. Moreover, the phylogenetic evaluation printed that the CHIKV traces we studied belonged to the East, Central, and Southern African (ECSA) genotype, of the Indian ocean lineage (IOL), and possessed E1-K211E and E1-I317V mutations. Thus, this learn about offers perception for a higher grasp of CHIKV pathogenesis in acute infection, alongside with the genomic range of the modern CHIKV lines circulating in Thailand.
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