バイオプロセシングとバイオテクノロジーのジャーナル

A Fast Method to Reduce Ammonium and Lactic Acid Production in Industrial Animal Cell Cultures

Abstract

Albert Cwas

The accumulation of ammonium and lactic acid is a significant challenge in industrial animal cell culture, impacting cell growth, productivity and product quality. These by-products result from the breakdown of amino acids and glucose, respectively. Their buildup can lower the culture pH, diminish cell viability and reduce overall productivity. Consequently, effective strategies to minimize their production are essential for optimizing cell culture processes. This article investigates rapid and efficient techniques to reduce ammonium and lactic acid production in industrial animal cell cultures.