微生物学および病理学ジャーナル

The human microbiome plays a crucial role in maintaining our health and well-being. It consists of trillions of microorganisms, including bacteria, viruses, fungi and archaea, which reside primarily in our gut. This complex ecosystem, known as the gut microbiota, interacts with our body in various ways, influencing metabolism, immune function and even neurological processes. However, disruptions in the balance and diversity of the microbiome can lead to dysbiosis, which has been associated with a range of health conditions and diseases. This article explores the concept of microbiome dysbiosis, its causes and its impact on human health, highlighting the importance of maintaining a healthy microbiome for overall well-being.

The emergence and spread of antibiotic resistance among pathogenic bacteria pose a significant threat to global public health. Understanding the molecular mechanisms behind antibiotic resistance is crucial for the development of effective strategies to combat this problem. This article provides an overview of the key molecular mechanisms employed by pathogenic bacteria to evade the effects of antibiotics. It discusses the role of genetic mutations, horizontal gene transfer, efflux pumps, target site modification and biofilm formation in antibiotic resistance. By elucidating these mechanisms, researchers can identify potential targets for the development of novel antimicrobial agents and devise innovative strategies to prevent the spread of antibiotic resistance.

The main factors to be taken into consideration when evaluating patients with solid cancer and infectious diseases have been reviewed in this paper by a group of experts from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the Spanish Society of Medical Oncology (SEOM). A number of recommendations have been made about the use of vaccines, the management of vascular catheter infections, and the prevention of infections prior to specific surgical procedures, among other topics. Additionally, the standards for treating non-ebrile neutropenia and using colony stimulating factors were updated. They conclude by offering a number of suggestions for the care of cancer patients who have serious infections.