臨床神経学および脳神経外科ジャーナル

Coffee is one of the world's most researched and commonly consumed beverages. Coffee is grown mostly in Latin America, Asia, and Africa, and its trade is the second largest after crude oil, with a value of more than $10 billion. The Rubiaceae family has hundreds of different species of coffee. The two species cultivated for commercial purposes are Coffea arabica and Coffea canephora. As the general public becomes more aware of their nutrition, several issues about the impact of coffee on their health have arisen. Caffeine, chlorogenic acid, diterpenes, and trigonelline are some of the most frequent bioactive compounds found in coffee.

Plasma Exchange (PE) and Immunoadsorption (IA) are key therapeutic options for autoimmune diseases in a variety of medical fields. Their pathophysiological reasoning is primarily based on the elimination of autoantibodies and a favourable immune system regulation. From a theoretical standpoint, apheresis is a promising treatment approach since it works by removing pathogenic components rather than giving medicines that can have serious adverse effects. Multiple Sclerosis (MS) steroidrefractory relapse, myasthenia gravis, Autoimmune Encephalitis (AE), Guillain Barre Syndrome (GBS), and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) are among the neurological indications. Although PE and IA are frequently used in clinical practise, evidence for their efficacy and safety in the aforementioned indications is generally lacking. This is due to the fact that drugs and medical devices are treated differently in terms of regulatory approvals in most countries, that is indication-specific phase III studies are generally not required in order to gain approval. As a result, less is known regarding the efficacy of PE and IA in comparison to other treatment choices and to each other. Similarly, there is a complete dearth of understanding regarding the best treatment regimens for PE and IA.

To see if patient satisfaction after anterior cervical spine surgery can be predicted by preoperative Patient Reported Outcome Measures (PROMs) and rapid postoperative arm pain alleviation. The researchers conducted a retrospective study of prospectively collected data from 193 patients with cervical radiculopathy who had surgery at Aarhus University Hospital. Preoperatively, postoperatively, and at the 1-year follow-up, standardised questionnaires were utilised to assess demographics, clinical results, and complications. The Visual Analogue Scale for Arm Pain (VAS-AP) and Neck Pain (VAS-NP), the Neck Disability Index (NDI), the EQ-5D 3-level version (EQ5D3L), and satisfaction were all included in PROMs. Medical records were used to compile immediate upper extremity pain status. PROMs improved considerably (p<0.001), and the majority of patients (66%) were happy with the surgical outcome at follow-up. Complications and complaints occurred in 3.6% of intraoperative cases, 1.5% of in-hospital cases, and 43% of post discharge cases. When compared to patients with a symptom duration of less than 24 months, patients with a symptom duration of more than 24 months had substantially lower probabilities of being satisfied.