????????????????????????????????
?????????C????CHC????IFN???????????????????I??????????IFN????α-2?IFNAR-2???????????????????????????????????????IFNAR-2??????????????????SVR??????????????????????????
??????????????????????????????
??/??:???????? 28B (IL-28B) ???????????????????? (PEG-IFN) ?????? (RBV) ??????? C ??? (CHC) ?????????????? (SVR) ?????????????????????? (Mo) ??? 1 ? IFN ??? 2 (IFNAR-2) ?????? IL-28B ???????????????????????????????????
?????: PEG-IFN ? RBV ????????????? 1b ????????? CHC ?? 148 ????????????????? Mo ??? IFNAR-2 ??????????????? 28 ?????????? (MFI) ???????????148 ???? 83 ??????? (rs8099917 ? IL-28B ?????) ????????
??: rs8099917?????TT????????????SVR????SVR????????Mo?MFI?????????????????7???14??????Mo?MFI??rs8099917?????TG??SVR?????SVR?????????????
??: IFNAR-2 ??????? IL-28B ?????? CHC ?????? PEG-IFN ??? RBV ??????????????????
?????????? TS ??????? ??
?????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????2011?11???2012?1????3????????796????????920?????????1694???????????????????????????????1694?????????????124?????????????????208?????588????????1??????456??2??????354??3????????110????? 222???????????>10 gms%?330???7.1-9.9 gms%?250???<7 gms%????????????????100??????????369???????????451????????????????136?????1??????????660?????2??????????????3???????????????1?20.3?????????IP?OP???????1?26.4?????????IP????1?18.4?????????450?????????????735???????????????????????????????????????????????????????????????????????????????????????????????????????????????
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