生物工学および生物医学科学ジャーナル

Chemotherapy, uterine injuries, fallopian tube occlusion, massive intrauterine adhesions, congenital uterine malformations and hysterectomy have all been shown to have a significant impact on female infertility and bioengineering techniques have shown great promise in this regard. The following are two broad categories that apply to these strategies: I) Transplantation of new or cryopreserved organs into the host and (ii) tissue designing methodologies that use a mix of cells, development factors and biomaterials that use the body's inborn capacity to recover/fix conceptive organs. The source of the organ and the immunogenic effects of allografts remain challenging despite whole organ transplant's success. Tissue engineering techniques can avoid these problems, but they haven't been shown to be effective at creating whole organ structures. We present a synopsis of the most recent developments in the treatment of female infertility using bioengineering.

Due to issues with oral drug delivery methods, transdermal drug delivery with microneedles is gaining popularity. Gastrointestinal course opens the medication to corrosive and catalysts present in the stomach, prompting denaturation of the compound and bringing about unfortunate bioavailability. In order to increase patient compliance, microneedle transdermal drug delivery addresses the issues associated with oral administration and alleviates patients' injection-related discomfort. Microneedles can be comprehensively characterized into five sorts: coated microneedles, dissolving microneedles, hollow microneedles and hydrogel-forming microneedles are all types of microneedles. The various applications and characteristics of a microneedle are determined by the materials used to prepare it. Due to their minimal invasiveness and ability to penetrate the stratum corneum barrier of the skin, polymeric microneedle arrays offer an improved method for the transdermal administration of drugs. The review provides a synopsis of the significance of the polymeric microneedle as well as a discussion of some of the most significant therapeutic drugs in research, particularly protein drugs, vaccines and small molecule drugs in regenerative medicine.