臨床消化器病学ジャーナル

Nutritional support and intervention are essential aspects of managing head and neck cancer. Many patients with this condition are malnourished upon diagnosis, and most of those undergoing treatment will require nutritional assistance. This paper offers a concise summary of key nutritional considerations for these patients and offers practical recommendations for clinicians in their care. Due to the potential impact of head and neck cancers on swallowing and eating, early nutritional assessment is critical. This evaluation typically includes an assessment of the patient's weight history, dietary intake, and physical examination.

Psychological factors can include thoughts, emotions, attitudes, and perceptions related to food and eating, this indicates that the study is interested in how these psychological factors affect the dietary choices and eating patterns of people living with MND. It's important to note that MND is a neurodegenerative disease that can impact motor functions, making it relevant to investigate how psychological factors might influence nutritional behaviour in this specific patient population. This suggests that the study is focused on identifying and comprehending the mental and emotional aspects that play a role in influencing nutritional choices and habits in individuals with MND.

Background: Hiatal hernia remains a serious medical concern, which occurs quite frequently in the general population, and is characterized by a wide range of non-specific symptoms. Many studies have highlighted the association of hiatus hernia with changes in the distal oesophageal mucosa. Despite the burden of hiatus hernia, little is known about the endoscopic and histopathological changes in the gastric fundus mucosa in patients presenting with this condition and it is known that malignancies involving the fundus and cardia carry a worse prognosis.

Objective: To assess the endoscopic and histopathological findings of gastric fundus mucosa in patients diagnosed with Hiatus hernias at Endoscopy.

Methods: A cross-sectional descriptive study of 120 patients diagnosed with hiatus hernia at St. Francis hospital, Nsambya, Kampala was conducted from 1st August 2022 to 28th February 2023. Diagnosis of hiatus hernia at Gastrointestinal Endoscopy and a hill classification of hiatus hernia was documented. Biopsies were taken from the herniating part of the gastric fundus for histopathological assessment. Data on demographics, medical history, endoscopy and histopathological findings were collected using a pre-tested questionnaire. Data were analyzed using STATA version 16.0.

Results: Among the 120 patients diagnosed with hiatus hernia, 55% were male. The mean age was 42 ± 15.9 years.72% had H. pylori infection. On endoscopy, 5 (4.2%) had normal endoscopy findings, 109 (95%) mucosal hyperemia, 43 (37%) ulcerations; 13 (11%) incarceration. Neither had gangrene nor tumors. None of the patients had normal histopathological findings: 11 (9%) atrophic (chronic) gastritis, 103 (86%) non-atrophic gastritis, 24 (20%) Gastric intestinal metaplasia.

Conclusion: Majority of patients diagnosed with hiatus hernia had abnormal gastric fundus endoscopy findings, and of concern were the 29% of patients that had Atrophic Gastritis and Gastric intestinal metaplasia that are both premalignant lesions.