人類遺伝学と発生学

Unveiling Cell Cycle-related Telomere Dynamics through 3D Super-resolution Nuclear Q-FISH Imaging

Abstract

Fransis Walin*

Telomeres play a crucial role in maintaining genomic stability, and their dynamics throughout the cell cycle are of immense interest in understanding cellular processes and diseases such as cancer. Conventional imaging techniques often fall short in capturing the intricate details of telomere changes during the cell cycle. However, recent advancements in 3D super-resolution imaging coupled with quantitative Fluorescence In Situ Hybridization (Q-FISH) have provided unprecedented insights into the dynamic behavior of telomeres. This article explores the significance of 3D super-resolution nuclear Q-FISH imaging in revealing cell cycle-related telomere changes, shedding light on its implications in cellular biology and disease pathology.