分子遺伝医学

The Software Development and Design Based Approach in Assessing the Probability of Essential Hypertension Disease

Abstract

Nagay AV, Khamidullayeva GA, Srojidinova NZ, Hafizova LS, Moon OR and Nagaev SD

Background and objectives: Software design and development for cardiovascular genetics laboratories.

Materials and methods: Integrated development environment-Delphi 7.0, Pascal language. In this program were laid down results of a retrospective analysis of hypertensive patients hospitalized in the Department of Arterial Hypertension (AH) of the Republican Specialized Center of Cardiology (RSCC) for the period from 2011 to 2013 y., passed the clinical and genetic testing according to the plan of Research Project ADCC-15.13.1. The study included 100 healthy volunteers and 800 patients with I-II grade of essential hypertension EH, all of them were Uzbek males in the mean age of 48.3 ± 8.1 yrs. The study was approved by the medical ethical committee of the center of cardiology, Tashkent Uzbekistan. Informed consent was obtained from each individual recruited.

Results: We have attempted to develop «CDS» application for the genetics cardiology department. For support parameters, we took the results of SNP-genotyping cardiovascular markers, biochemical, clinical parameters, as well as nutritional status. We have developed «GeneSecure» platform with «CDS» for IBM Pentium, Windows OS.

Conclusion: The polygenic nature of EH and incomplete update patient records significantly reduce diagnostic effect of the CDS. However, in some cases, the CDS are not always able to clearly determine the synergistic and intergenomic effect of analyzed genes. These issues occur when the volume of new data exceeds the amount of filer memory, leading to the appearance of these areas, which are very difficult to manage.