腎臓学と治療学ジャーナル

The Role of the Immune System in the Pathogenesis of Diabetic Nephropathy

Abstract

Maria-Gabriela Velez ,Vivek Bhalla *

Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD) in adults. Despite our current understanding of the disease, we cannot accurately predict which patients with diabetes will develop nephropathy, and we cannot halt the progression to ESRD. Research on the role of the immune system in DN may shed light on novel biomarkers and therapies for this severe complication of diabetes mellitus. In this review we examine the current knowledge of the role of immune system in the development and progression of diabetic nephropathy, speculate on the potential role of B lymphocytes, and highlight implications for prognosis and therapy.