腎臓学と治療学ジャーナル

Sympathetic Activity in Dahl Salt-Sensitive Hypertension - Why is a Nitric Oxide-Induced Inhibitory System Up-Regulated in the Sympathetic Center?

Abstract

Yasuhiro Nishida *,Megumi Tandai-Hiruma ,Takehito Kemuriyama ,Kohsuke Hagisawa

In essential hypertension, peripheral sympathetic nerve activity is generally thought to be increased regardless of salt sensitivity or insensitivity. Recent reports suggest that the cause may be abnormal central nervous system enhancement. However, other several reports have shown that a central sympathetic inhibitory system, the neuronal nitric oxide synthase system, may be strongly enhanced in salt-sensitive hypertensive Dahl rats, an animal model of salt-sensitive hypertension. These two facts lead to questions what happens finally in peripheral sympathetic activity and what is the relationship between sympathetic nerves and hypertension. In this review, we will show evidences for enhancement of central sympathetic inhibitory system, putative cause for up-regulation of central neuronal nitric oxide synthase system, and a role of its function, then lastly we consider the relationship between hypertension and sympathetic nerves in a rat model, with a focus on salt-sensitive hypertension.