Dejan Spasovski *,Tatjana Sotirova
Aim: The aim of this study was to detect and compare the enzymes, globulins and reactants of the early phase in patients with untreated rheumatoid arthritis and to reveal the effect of untreated rheumatoid arthritis on tubular function and sensitivity on brush border area. Material and Methods: The samples of serum and urine were examined in 70 participants (35 patients with untreated rheumatoid arthritis, 35 individuals of the healthy control group). We used in the study the kinetic assay for determination of alanine aminopeptidase (AAP) (Standards methods under IFCC), γ-glutamiytransferase and MEIA (Microparticle Enzyme Immunoassay) (Abbot Axsym system) for detection of β 2-microglobulin in urine. Results: Of 35 patients with RA, 16 patients showed presence of γ-GT (sensitivity of the test - 45.71%), 24 patients showed presence of AAP enzymuria (sensitivity of the test - 68.57%), while the presence of β2-microglobulin in urine was very low (sensitivity of the test - 0%). From 18 RF negative patients, 14 patients were AAP positive, 10 patients were γ-GT positive, while the presence of β2-microglobulin in urine was not detected. Among 17 RF positive patients with RA, the presence of AAP was detected in 10 patients, the presence of γ-GT in 6 patients, while the presence of β2-microglobulin in urine was not detected. Conclusion: In untreated rheumatoid arthritis AAP had higher sensitivity than γ-GT and β2-microglobulin in detection of asymptomatic renal damage
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