移植技術と研究

Pre-treatment Modulation of Renal Allograft Chemokine: Glycosaminoglycan Pathways Reduces Transplant Rejection

Abstract

Michelle Burgin, Roxana Beladi, Kyle Varkoly, Jordan R. Yaron, Liqiang Zhang, Steve T. Yeh, Jacqueline Kilbourne, Dara Wakefield, William Clapp, Alexandra R. Lucas

With over a hundred thousand transplants needed every year and limited availability leading to the death of 20 patients each day, long term viability of solid organ transplants is imperative. Early allograft transplant rejection is well controlled by immunosuppression of T cells, but late organ loss due to allograft vascular (AV) disease and chronic immune damage are unmet medical needs. Chronic AV disease and ongoing immune damage are leading causes of late transplant organ loss. In prior work, we demonstrated that implant of an allograft kidney with a conditional deficiency of the N-deacetylase N-sulfotransferase 1 (Ndst1^-/-) enzyme in the endothelium and myeloid precursors (C57Bl/6 background) led to a significant decrease in early rejection after implant into wild type BALB/c mice with normal Ndst1 expression.