繊維科学および工学ジャーナル

PLGA Copolymer Synthesis and Nanofabrication by Electro and Melt Spinning

Abstract

Savita H Bansode*, Priyanka Vasant Khare and PA Mahanwar

Polylactic Glycolic Acid (PLGA) is most important polymer in biomedical applications because we can modify the degradation rate by copolymerization ratio, processing. The ideal scaffold should be three dimensional, highly porous, biodegradable and biocompatible without immune reaction or inflammation. In addition, it should have proper mechanical properties to support the growth of new tissue. Increased in the use of electrospinning nanofiber technique to create nanofiber scaffold for tissue engineering, as there are reports that these scaffolds successfully promote to cell matrix and cell-cell interactions with the cells of human body. Now days, success have been achieved in skin, bladder, airway, bone, kidney where tissue engineering construct has been successfully used.

PLGA synthesis done by convectional method, with study of various parameter such as time, temperature, monomer and catalyst ration. PLGA can be synthesized by polycondensation (convectional) method at 130°C, for 25 hours. Important characteristics such as melting temperature, glass transition temperature, and degradation temperature was determined by DSC and TGA analysis, it was obtained as 168.44°C, 55.76°C and 87.61°C respectively. Chemical structure was studied by FTIR and NMR. These results helped to study the effect of monomer, catalyst on reaction and determining the parameters for melt and electro spinning. Because of good biocompatibility and biodegradability, they can be used in various areas, such as long-term release systems and the tissue engineering.