Zhang Xinhuai, Wang Xiaoqun, Miao Jinchao, Liu Zanwei, Lin Xiaofeng, Huang Jiarong, Shi Shange and Wu Hui
Background and objective: Liposarcoma arising from colonic mesentery was rare and its biological behavior and clinical management is not well known. We aimed to explore the clinicopathological features and management of liposarcoma in colonic mesentery by presenting a case of pleomorphic liposarcoma of sigmoid mesentery with literature review.
Methods: A patient of sigmoid mesentery pleomorphic liposarcoma was successfully treated in Pengpai Commemorative Hospital. With this case included, there were total of 10 cases of colonic mesentery liposarcoma reported by reviewing literature from English database. Clinical and pathological features, treatment and prognosis were analyzed.
Results: The patient underwent complete tumor resection successfully, and had an uneventful recovery after surgery. Of total 10 patients, the median age was 49 years, with tumor size from 2 cm to 50 cm. In pathology, 4 (40%) were of well-differentiated, 3 (30%) of mucinous, 1 dedifferentiated, 1 pleomorphic, and 1 case of primary mucinous liposarcoma from the sigmoid mesocolon accompanied with well-differentiated liposarcoma in the pelvis. Eight of 10 patients had follow-up data. The median follow-up period was 21 months. Recurrence was recorded in 2 cases (25%), of which 2 cases were mucinous liposarcoma.
Conclusion: Sigmoid mesocolic pleomorphic liposarcoma is rare and of unfavorable prognosis. Complete resection is the mainstay of treatment. Tumor size and complete resection with clear margin are the main prognostic factors.
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