分子遺伝医学

Frequency of Chromosomal Abnormalities in Subpopulations of Infertile Males among Chinese Hakka Population

Abstract

Zhao P, Gu X, Wang H and Yang M

The frequency of chromosomal abnormalities is supposed to be elevated in infertile males as well as shown negative correlation of sperm concentration. Cytogenetic analysis, recommended by guidelines in infertile men, is expensive. Hence, it may be good for recognize riskiest men with chromosomal abnormalities, potentially by analyzing sperm concentration outside of the parameters. Aim to evaluate the frequency of chromosomal abnormalities in different subpopulations among Hakka population, we assessed several clinical parameters in infertile men. A total of 1291 azoospermic men and men apply for in-vitro fertilization (IVF) treatment, were analyzed for semen parameters, hormone levels, Y chromosome microdeletions and medical history, related to chromosomal abnormalities. Chromosomal abnormalities were detected 46 of 1291 men (3.6%) in our study. Correlation was no shown between chromosomal abnormalities and sperm parameters except for sperm volume (OR 0.76, P=0.029). Significantly, azoospermia was related to an increased frequency of chromosomal abnormalities (OR 32.24, P<0.001). Elevated gonadotropic hormone levels, meaningfully, was related to the risk of carrying a chromosome abnormality (OR 4.38, P<0.001). Lower rate of chromosomal abnormalities was observed in infertile males with positive andrologic history (OR 0.21, P=0.003). Previous miscarriages, related to an increased frequency of chromosomal abnormalities, were discovered in non-azoospermic men (OR 4.78, P=0.003). The results indicated that azoospermic men with hypergonadotrophic as well as an eventless andrologic history have frequently risk of chromosomal abnormalities.