移植技術と研究

Fibrin Sealant and Femtosecond Laser Assisted Keratoplasty: Initial Results

Abstract

Tatiana MB Prazeres, Elissandro MS Lindoso, Leon Grupenmacher and Luciene B Sousa

Purpose: To evaluate whether the use of a sealant combined with interrupted suture would provide better visual outcomes and better post-operative recovery to keratoconic patients compared to interrupt and running sutures without the use of sealants using femtosecond laser assisted keratoplasty.

Methods: A prospective, randomized study of 12 patients (12 eyes) with keratoconus was conducted, randomized into two treatment groups. The no glue group (6 eyes) underwent penetrated keratoplasty (PK) with femtosecond laser assisted keratoplasty shaped (mushroom) and combined suture (8 interrupted suture and 8 running sutures) while the glue group (6 eyes) underwent the same procedure but their incisions were closed with 8 interrupted sutures and sealant.

Results: The no glue group had a mean BCVA of 0.2 (LogMar). The glue group had a mean BCVA of 0. (LogMar). p=0.028 Transplants with glue were well positioned showing good healing but presented more inflammation in the first week post-surgery. Regarding refractive outcomes, there was no difference between the groups.

Conclusions: There were no statistical difference between the two groups regarding BCVA and refractive errors. The use of sealants produced more inflammation. Further studies with a larger number of patients and longer follow up would be needed to confirm these findings.