製剤科学とバイオアベイラビリティのジャーナル

Enhancing Drug Delivery: Formulation Techniques and Bioavailability Evaluation

Abstract

Suñé Negre

The optimization of drug delivery is crucial for improving therapeutic outcomes in pharmaceutical sciences. This article explores formulation techniques and bioavailability evaluation methods essential for refining drug delivery systems. Nanoformulations like nanoparticles, liposomes, and micelles offer benefits such as increased solubility and targeted delivery. Lipid-based delivery systems, such as nanoemulsions and solid lipid nanoparticles, utilize lipids to enhance drug absorption and stability. Controlled release systems, prodrug design, and pharmacokinetic studies further optimize drug delivery by modulating release kinetics and improving bioavailability. In vitro-in vivo correlation and advanced imaging techniques provide precise evaluation of drug bioavailability and distribution. Integrating formulation science and bioavailability assessment promises the development of safer more effective drug delivery systems, advancing pharmaceutical innovation for improved patient care.