免疫化学と免疫病理学

Decoding Cross-presentation: Unravelling MHC-mediated Molecular Functions and Regulatory Mechanisms

Abstract

Tindea Mechteleria*

Cross-presentation, a fundamental process in immunology, plays a pivotal role in the adaptive immune response by presenting extracellular antigens on Major Histocompatibility Complex Class I (MHC-I) molecules. This comprehensive review delves into the intricate molecular characteristics, functional definitions and regulatory mechanisms governing cross-presentation. The exploration encompasses the diverse cellular players involved in this process, emphasizing the central role of antigen-presenting cells, particularly dendritic cells. The review outlines the molecular machinery responsible for the generation of MHC-I/peptide complexes from exogenous antigens, shedding light on the precise mechanisms that orchestrate cross-presentation. Furthermore, the regulatory checkpoints governing the efficiency and specificity of cross-presentation are dissected, providing insights into the dynamic interplay between the immune system and its surrounding microenvironment. This comprehensive analysis serves to enhance our understanding of cross-presentation, offering a foundation for future research and potential therapeutic interventions that leverage this critical immunological process.