血液とリンパのジャーナル

染色体 1 の異常は、自家造血細胞移植を受ける高リスク多発性骨髄腫患者の無増悪生存期間および全生存期間の短縮を予測する、後ろ向き分析

Abstract

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??? (ch)1 ?????????? (MM) ????????????????????????????????? (auto-HCT) ????????????????????????????????????? MM ??? ch1 ?? (1q ???1p ???ch1 ??) ???????ch1 ????????? MM ??????????????????????????????????????????????MM ???????? 1 ???????????????? 232 ???? (169 ?????63 ????) ??????????????? ch1???n=15??????????HCT???????n=6??????PFS?p<0.001?HR= 22.93?95% CI?4.94-106.48????OS?p = 0.0002?HR= 21.22?95% CI?1.18-14.98?????????????????????ch1?????del 13q?n=7??????????PFS???OS?????????4.76???9.43??????ch1???????del 13q???n=8???????16.79???35.22?????????????????????????24.44???57.03??????????????? ch1 ????? HCT ????????????????????????????????????