人類遺伝学と発生学

Chromosomal Abnormalities in Reimplantation Development

Abstract

Anver Kuliev, Zev Zlatopolsky and Svetlana Rechitsky

Direct testing of the outcome of human female meiosis demonstrated that up over a half of oocytes from IVF patients of advanced reproductive age are aneuploid, originating comparably from meiosis I and meiosis II errors, with potential probability of aneuploidy rescue in an almost half of oocytes with sequential first and second meiotic errors. One fifth of abnormalities originating from meiosis I and II are of complex nature, with nonrandom distribution of chrmomatid/chromosome (10:1 ratio), and missing/extra chromotid (chromosome) errors (2:1 ratio). The data also demonstrate the relationship between embryo viability and meiotic origin of chromosomal errors, affecting their clinical impact on preimplantation and post-implantation development