組織科学工学ジャーナル

Autologous Bone Marrow Transplantation in Osteonecrosis of the Femoral Head

Abstract

Ji-hyo Hwang, Soo-ho Lee, Ho-youn Park and Mi-jung Kim

Goal: This study evaluated clinical and radiological results of autologous bone marrow transplantation (BMT) for early stage osteonecrosis of the femoral head (ONFH) and analyzed prognostic factors. Materials and Methods: From November 2003 to January 2006, 49 hips in 43 patients with early stage ONFH underwent autologous BMT were followed for at least 2 years. For clinical results, preoperative and postoperative Harris hip score (HSS) were evaluated and survival rate was obtained at the point of performing the total hip arthroplasty. Radiologic results were assessed by changes in necrosis size on MRI performed preoperatively and postoperatively. To evaluate prognostic factors, survival rate was analyzed according to age, gender, etiology, and duration of the symptom.
Results: Postoperative average HHS was significantly increased and there were no significant changes in necrosis size on MRI. Eleven of the 79 hips were required the arthroplasty and the group with use of steroid and short duration of symptom less than 6 months showed lower survival rate.
Conclusion: Autologous BMT for early ONFH can be one of the treatments to improve clinical feature and delay radiologic progress. However the steroid-induced ONFG and short duration of symptom seemed to be poor prognostic factors.