血液とリンパのジャーナル

スーダン人の Gpx-198C/T 遺伝子多型 (rs1050450-198C/T) と糖尿病網膜症との関連性

Abstract

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????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????GPX-198C/T?rs1050450??????????GPX???????????????????????????????????FBS?HbA1c????????????????: ???? 130 ??????????????????? (n 60) ?????????????????? (n 70) ?????????? 22 ??? 80 ???Makkah Eye Complex ????????DNA ?????GPX ????????? PCR ??? Aba1 ????????????????????????? GPX ???FBS?TG?CHOL?HbA1c ????????????????????????? Cobas Int 400 ??????????: ????????????????????????????? 2 ? =1.9:1 ???????????????????????????? II ?????? 1 ??????????????? (128 ??98.5%) ???? II ???????? I ??????? 2 ? (1.5%) ???? GPX ?????DR ????? DNR ???????? (p=0.003)??? HbA1c ??? FBG ???????? p=0.001 ??? p=0.001 ??DR ??? DNR ???????????????????? CHOL ??? TG ?????DR ? DNR ????????????????????? GPX-198C/T ??????????CC ???????? 33 (47%) ????? 13 (22%) ??????????CC ?????GPX-198C/T SNP rs1050450 ????????????????????? (OR=0.310?95% CI=0.176-0.486?p=0.001)????TT ????????? 25 (42%) ???????????????? 14 (20%) ????????????SNP?TT?GPX-198C/T SNP rs1050450 ????????????????????? (OR=2.4?95% CI=1.10-5.90?p=0.004)?????????? C ????????? 48% ??????????? T ?????????????? 72% ????OR=0.357 (0.216-0.433)?p=0.001 ??????: ???????GPX-198C/T (rs1050450) ??????????????????????????????????????????????????????? T ????????GPX ????????????????????????