核医学と放射線治療

The Journal of Nuclear Medicine and Radiation Therapy is a prominent journal which published articles globally in the field of nuclear medicine, radiation therapy and its applied fields. It is an open access journal that aims to publish the most complete and reliable source of information on discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in this field and provide online access to the researchers worldwide in electronic forms are immediately freely available to read download and share to improve the Open Access motto without any restrictions or subscriptions. The articles are peer reviewed by journal’s eminent Editorial Board and the manuscripts are peer reviewed by potential reviewers according to their research interest.

The Linear Quadratic model (LQM) is an extended version of the linear non threshold (LNT) model, which has been used for quantitative description of radiation protection, radiation therapy and animal experiments for long time. However, the LQM encounters serious pitfalls, especially for the case of the fractionation irradiation. We propose the 'Whack a Mole' (WAM) model as a post LQM framework of the radiation and risk estimation, which includes cell exclusion effect. By introducing the time dependence, the WAM model explicitly includes not only the total dose but also the dose rate dependence. We show various important results of the WAM model for the dose rate dependence, the fractional irradiation effect, and the spontaneous decrease effect on mutation frequency. As an application of the WAM model, we apply the WAM model to the mega mouse experimental data taking into account the delay time of mating after irradiation.