微生物学および病理学ジャーナル

Microbial susceptibility surveillance and management are critical components of infection control and antimicrobial stewardship programs. With the increasing threat of antimicrobial resistance, it is imperative to implement effective strategies to monitor microbial susceptibility patterns and manage resistant organisms. This article explores various strategies for enhancing microbial susceptibility surveillance and management, including the use of advanced diagnostic techniques, implementation of antimicrobial stewardship programs, promotion of infection prevention measures and fostering collaboration among healthcare professionals. By employing these strategies, healthcare facilities can better identify emerging resistance patterns, optimize antimicrobial therapy and ultimately mitigate the spread of antimicrobial resistance.

Autoinflammatory diseases represent a group of disorders characterized by dysregulated immune responses leading to recurrent episodes of inflammation without an identifiable external trigger. These conditions pose significant challenges in diagnosis and management due to their heterogeneous nature and overlapping clinical features with other inflammatory disorders. Recent advances in immunology, genetics and molecular biology have shed light on the underlying pathological mechanisms driving autoinflammatory diseases, unveiling novel therapeutic targets and diagnostic strategies. This article provides an overview of the current understanding of the pathological basis of autoinflammatory diseases, highlighting the key molecular pathways involved and the implications for clinical practice.

The immune system is a sophisticated network of cells, tissues and organs that protects the body against pathogens and maintains tissue homeostasis. However, this defense mechanism is not always foolproof and diseases can arise when the immune system malfunctions or is dysregulated. This article delves into the intricate relationship between the immune system and various diseases, highlighting how dysregulation of immune responses can lead to both inflammatory and autoimmune conditions. Additionally, it examines how pathogens evade immune detection and exploit host defenses, contributing to the pathogenesis of infectious diseases. Understanding these complex interactions is crucial for the development of effective therapeutic strategies to combat a wide range of illnesses.

With the rise of antibiotic-resistant microbes, the traditional approach to microbial susceptibility management faces significant challenges. In a post-antibiotic era, alternative strategies become imperative to combat microbial infections effectively. This article explores various alternative approaches to managing microbial susceptibility, including phage therapy, probiotics, immunomodulation, antimicrobial peptides and innovative drug delivery systems. Understanding and implementing these alternative approaches are crucial for addressing the pressing issue of antibiotic resistance and ensuring sustainable treatment options for microbial infections.