がん臨床試験ジャーナル

Pancreatic Ductal Adenocarcinoma (PDAC) stands as one of the most lethal forms of cancer with limited treatment options and poor prognosis. The hallmark of PDAC is its resistance to conventional therapies, urging the exploration of targeted therapeutic approaches. In recent years, significant progress has been made in understanding the oncogenic pathways driving PDAC development and progression. This article provides an overview of the clinical and preclinical strategies targeting these pathways, offering insights into promising avenues for the treatment of this deadly cancer.

An ultrasensitive DNA-biomacromolecule system or technology has the capability to detect and analyze DNA molecules with exceptional sensitivity. DNA, serving as the fundamental genetic material in living organisms, holds critical significance in numerous biological processes and finds extensive applications in diagnostics and research. Ultrasensitive DNA-biomacromolecule technologies are specifically engineered to identify and quantify minute amounts of DNA molecules within a given sample. Employing diverse detection methodologies such as fluorescence, electrochemical sensing, nanopore sequencing, or amplification techniques like polymerase chain reaction, these technologies enable scientists to achieve remarkably precise and sensitive detection of DNA molecules, even when present in exceedingly low concentrations.

Lung cancer remains one of the most prevalent and deadly cancers worldwide. The journey of a lung cancer patient is fraught with challenges, from diagnosis to treatment and beyond. However, empowering patients with knowledge and providing them with adequate support can greatly enhance their ability to navigate this complex disease. This research article explores the significance of empowering lung cancer patients, highlighting the role of knowledge and support in improving patient outcomes and overall quality of life. It also discusses various strategies and resources that can be employed to empower patients throughout their lung cancer journey.

Lung cancer is a significant global health concern, accounting for a substantial number of cancer-related deaths annually. The journey of a lung cancer patient is multifaceted, encompassing diagnosis, treatment decision-making, treatment administration, side effect management, and survivorship. This article emphasizes the importance of empowering patients with knowledge and support throughout this journey to enable them to actively participate in their care and make informed decisions.

Lung cancer remains a significant global health challenge, with a high mortality rate and a substantial impact on patients and their families. Navigating the complexities of lung cancer, from diagnosis to treatment and survivorship, requires comprehensive support and knowledge empowerment for patients. Empowering lung cancer patients with information and support plays a crucial role in improving their outcomes, enhancing treatment decision-making, and ultimately improving their overall quality of life.

Lung cancer is a leading cause of cancer-related mortality worldwide. Despite advancements in treatment modalities, the prognosis for lung cancer patients remains poor. However, recent developments in targeted therapies have shown promising results in revolutionizing lung cancer treatment. This research article aims to provide an overview of targeted therapies and their impact on lung cancer treatment. We discuss the underlying mechanisms of targeted therapies, current targeted therapy options, challenges, and future directions in this rapidly evolving field.

Lung cancer is a complex disease with diverse molecular subtypes, and traditional treatment approaches such as surgery, chemotherapy, and radiation therapy have limitations in effectively managing advanced stages of the disease. Targeted therapies, which focus on specific molecular alterations driving cancer growth, have emerged as a breakthrough in lung cancer treatment.

Targeted therapies exploit specific molecular aberrations in cancer cells, including gene mutations, amplifications, or rearrangements. These alterations may activate signaling pathways involved in tumor growth and survival. By inhibiting these aberrant molecular targets, targeted therapies aim to disrupt tumor growth and improve patient outcomes.

Lung cancer remains a leading cause of cancer-related deaths worldwide. However, many cases of lung cancer are preventable through the promotion of healthy lifestyles and raising awareness. This research article aims to explore the significant role of healthy habits, such as tobacco control, diet modification, regular exercise, and early detection, in preventing lung cancer. It emphasizes the importance of public health campaigns, education, and policy interventions in creating a societal shift towards healthier choices and reducing the burden of lung cancer.

Lung cancer is a significant public health concern, accounting for a substantial number of cancer-related deaths globally. Despite advances in treatment, prevention remains the most effective strategy to combat this disease. This article highlights the importance of promoting healthy lifestyles and creating awareness to prevent lung cancer.

Background: Breast Cancer (BC) is still a global public health issue that affects both industrialized and developing nations. It is the type of cancer that affects women most frequently in sub-Saharan African nations, particularly in Ethiopia. Despite the overwhelming difficulty, Ethiopian researchers have not yet identified the factors linked to mortality. Aside than that, there aren't many studies in this field. Therefore, the main goal of this analysis was to identify the most important factors that contributed to BC patients in Northern Ethiopia having shorter survival times.

Methods: 146 women in Northern Ethiopia who had BC were the subjects of an institutional-based retrospective cross-sectional study design that ran from September 12, 2015, to March 9, 2019. The STATA 14 program was used to conduct the statistical analysis. In order to identify predictors, a log-normal regression model and the Kaplan-Meier curve were both used.

Results: In Northern Ethiopia, the overall death rate prevalence was 18.5%. Retrospective monitoring of the chosen patients lasted an estimated 28.12 months on average. The age range of patients was 23-78 years with a median of 48 years. The multivariable Lognormal model analysis revealed, being distant metastatic ATR=0.52, CI=(0.341, 0.787), regional metastatic (ATR=0.63, (0.423, 0.924)), age (ATR=0.98, 95% CI: (0.968-0.997), baseline tumor size (ATR=0.98, 95% CI: (0.968, 0.996), clinical stage IV ATR= 0.48, 95% CI: (0.297-0.789), illiterate ATR=0.52, 95% CI: (0.325-0.823), and Rural residence ATR=0.68, 95% CI: (0.516-0.904) were found to be critical risk factors of time to death breast cancer patients.

Conclusion: The prevalence fatality rate among BC patients in Northern Ethiopia remains a serious public health issue, the research showed. Being clinical stage IV, distant and regional metastasis, illiteracy education level, baseline tumor size, rural residence, and old Age were discovered to be the most significant risk factors for patients' time to death. As a result, the government and other interested parties must address educational possibilities; raising awareness about the diagnosis of advanced disease and providing helpful advice on screening programs in a timely manner will lower the death rate and increase patient survival.

Lung cancer is a major cause of cancer-related deaths worldwide. However, advancements in medical imaging and diagnostic technologies have enabled the early detection of lung cancer, leading to improved patient outcomes and survival rates. This research article explores the significance of early detection in saving lives from lung cancer by examining current screening methods, diagnostic techniques, and their impact on patient care. It also discusses the challenges and future directions of early detection strategies for lung cancer.

Lung cancer is a global health concern, responsible for a significant number of cancer-related deaths each year. Late-stage diagnoses contribute to poor prognosis and limited treatment options. Therefore, early detection has become crucial in reducing mortality rates and improving patient outcomes. This article highlights the power of early detection in lung cancer, emphasizing its potential to save lives and enhance disease management.

This research article explores the power of early detection in saving lives from lung cancer by examining current screening methods, diagnostic techniques, and their impact on patient care. Various screening approaches, including chest X-rays, Computed Tomography (CT) scans, low-dose CT screening, and biomarkers, are discussed. Diagnostic techniques such as imaging, molecular and genetic testing, liquid biopsies, and artificial intelligence are also explored. The article highlights the positive impact of early detection on patient care, including improved survival rates, informed treatment decision-making, and reduced healthcare costs.

Challenges in early detection, such as false positives, accessibility, and education, are addressed. Finally, the article discusses future directions and innovations in early detection strategies, including advancements in imaging technology, integration of biomarkers and genetic testing, and personalized screening approaches. The power of early detection in lung cancer is underscored, emphasizing the need for widespread adoption and continued research to save more lives from this devastating disease.

Lung cancer remains a significant global health concern, accounting for a substantial number of cancer-related deaths. Understanding the causes, recognizing the symptoms, and implementing preventive measures are crucial for combating this disease. This research article aims to delve into the multifaceted aspects of lung cancer, shedding light on its causes, symptoms, and the importance of prevention strategies. By examining the latest scientific research and clinical findings, we hope to provide a comprehensive overview that will aid in raising awareness, early detection, and reducing the burden of lung cancer.

Lung cancer is a complex disease influenced by a combination of genetic, environmental, and lifestyle factors. This section provides an overview of the current global burden of lung cancer and highlights the need for research, prevention, and effective strategies to combat this deadly disease.

This section explores the primary causes of lung cancer, with a particular focus on tobacco smoke, including active and passive smoking. We delve into the harmful constituents of tobacco smoke, the mechanisms of carcinogenesis, and the increased risk associated with prolonged exposure. Furthermore, we discuss other risk factors, such as occupational hazards, air pollution, radon gas, and genetic predisposition, emphasizing their impact on lung cancer development.