がん臨床試験ジャーナル

Lung cancer signifies to a critical issue for general wellbeing around the world. Lung carcinoma is a threatening lung tumour portrayed by uncontrolled cell development in fleshy tissue of the lung. This development can spread past the lung by the procedure of metastasis into close-by tissue or different parts of the body. Most malignancies that begin in the lung, known as essential lung diseases, are carcinomas. The two fundamental sorts are Small Cell Lung Carcinoma (SCLC) and Non-Small Cell Lung Carcinoma (NSCLC). The most widely recognized manifestations are blood slashing (counting hacking up blood), weight reduction, shortness of breath, and chest pains . Most of the Lung cancer cases are due to Tobacco or its other product involved nicotine

A correlation between the over expression of Osteopontin (OPN), E-cadherin, β-catenin, and cyclooxygenase 2 and poor prognosis has been previously suggested in solid tumors. The aim of the ITACA-S translational study was to further investigate the correlation of these immunohistochemical biomarkers with the outcome of radically resected gastric cancer patient. The immunohistochemistry expression of osteopontin, E-cadherin, β-catenin, and cyclooxygenase 2 was detected in 346 primary gastric tumor tissue samples from patients enrolled in the ITACA-S trial which randomized patients to receive adjuvant chemotherapy with ether 5-fluorouracil and leucovorin or a sequential regimen of infusional 5-fluorouracil and leucovorin plus irinotecan followed by cisplatin and docetaxel. A higher expression of OPN was associated to diffuse histotype, high grade and peritoneal relapse, but not with TNM stage. It was associated with higher risk of recurrence and metastases. Furthermore, OPN overexpression was identify as an independent prognostic factor for both relapse-free and overall survival. The abnormal expression of E-cadherin or b-catenin was correlated with more advanced disease stage and a poor outcome.