生物医学および薬学ジャーナル

Problem-Based Learning (PBL) is a pedagogical approach that has gained significant attention in the field of education, particularly in the context of biomedical science master's courses. It involves presenting learners with real-world, complex problems that drive them to actively engage in problem-solving and critical thinking. As technology continues to shape the educational landscape, the integration of PBL with technological advancements, such as internet-mediated direct contact, has the potential to enhance the learning experience and better address the needs of contemporary learners. This article explores how PBL is employed in biomedical science master's courses, how technological reconstruction facilitates direct contact and synchronization via the internet, and the impact of these changes on the learner's educational experience.

Rheumatoid Arthritis (RA) is a chronic autoimmune disorder characterized by joint inflammation and damage. Tocilizumab, an interleukin-6 receptor inhibitor, has emerged as a promising treatment for RA. However, concerns exist about its safety and effectiveness in patients undergoing continuous haemodialysis treatment. This clinical report presents a comprehensive analysis of the safety and successful application of Tocilizumab in RA patients on continuous haemodialysis.

The COVID-19 pandemic has presented unprecedented challenges to healthcare systems worldwide. In severe cases, the virus can lead to Acute Respiratory Distress Syndrome (ARDS), necessitating advanced interventions such as Extracorporeal Membrane Oxygenation (ECMO). ECMO provides temporary mechanical support to the heart and lungs, allowing them to rest and heal. However, determining the success of ECMO in COVID-19 patients has become a critical concern. Lung ultrasound, a non-invasive imaging technique, has gained traction as a potential tool for predicting the success of ECMO in these patients. This article delves into the application of lung ultrasound in predicting the outcomes of COVID-19 patients undergoing ECMO.

The Mediterranean diet, renowned for its health-promoting effects, has long been associated with a reduced risk of cardiovascular and metabolic disorders. In recent years, advancements in multi-omics research have allowed scientists to delve deeper into the intricate mechanisms underlying these benefits. Employing humanized gnotobiotic rats as a model system, this study aims to elucidate the nutritive and oxidative consequences of a Mediterranean diet and oil-based supplements on cardiovascular and metabolic health. By integrating genomics, transcriptomics, proteomics, and metabolomics data, researchers are gaining unprecedented insights into the molecular pathways influenced by dietary interventions. This article reviews the current understanding of the Mediterranean diet, the significance of employing humanized gnotobiotic rats in research, and the insights garnered through multi-omics approaches regarding the diet's impact on cardiovascular and metabolic disorders.

The Covid-19 pandemic, responsible for over 6 million worldwide deaths, there was an urgent need for preventative measures to mitigate its effects. Conventional vaccines, which typically prevent or reduce disease severity, usually require more than a decade for development and commercialization. The pressing nature of the pandemic led to the pursuit of novel solutions like mRNA-based vaccines, playing a critical role in saving lives. This article highlights the potential of mRNA technology to go beyond infectious diseases, offering the possibility to change the treatment landscape of future malignant diseases and address unmet medical needs.