医療微生物学と診断

Vitamin D Supplementation May Prevent the Severity of Sars-Cov-2 Infection: A Prospective Study among Moroccan Health Professionals

Abstract

Hattoufi Kenza, Benlhachemi Sara, El Fahime El Mostafa, Heikel Jaafar, El Ammari Laila, Bigdeli Maryam, Benikrane Hasnae, El Haloui Noureddine, Aguenaou Hassan and Barkat Amina

Background: Vitamin D deficiency can increase susceptibility to viral infections such as Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). The current study has two aims; first, measuring 25-hydroxyvitamin D (25 (OH) D) concentration in a group of Moroccan health professionals, in order to determine the prevalence of hypo-vitaminosis D and to supplement those at risk. Second, conducting a 5-month flow-up; In order to detect individuals contracting SARS-CoV-2 infection, whether or not they manifest severe respiratory symptoms, and therefore to evaluate the impact of Vitamin D supplementation on their immune system.

Methods: This is a prospective, observational study, which had been occurred at Children’s hospital of UHC Ibn Sina of Rabat. Measurement of 25-hydroxyvitamin D was determined by ARCHITECT 25-OH VITAMIN D at the biochemistry laboratory of Ibn Sina Hospital in Rabat. After 25 (OH) D measurements, a supplementation of cholecalciferol 100,000 IU VITD 3 was administered according to its status for each participant.

Results: Sixty-five participants were enrolled in this study; 85% were females. The average value of 25-hydroxyvitamin D in the general population was 17 ± 7 ng/ ml, with extreme values of 7 and 34 ng/ml. Ninety-two percent of the studied population presented hypo-vitaminosis D. Thirteen participants (20%) were infected with SARS-CoV-2. Although, no cases required hospitalization or respiratory support.

Conclusion: It appears necessary to supplement individuals at risk of contracting respiratory viral infections, particularly health professionals who are on the front line against COVID-19 pandemic.