微生物病因学ジャーナル

The Role of Gut Microbiota in the Pathogenesis of Inflammatory Bowel Disease

Abstract

Annamaria Piemonte

Inflammatory Bowel Disease (IBD), encompassing Crohn's disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal tract with a complex etiology involving genetic, environmental, and immunological factors. Emerging evidence highlights the significant role of gut microbiota in the pathogenesis of IBD. This review explores the mechanisms by which dysbiosis, or microbial imbalance, contributes to intestinal inflammation. We examine the interactions between gut microbes and the host immune system, the impact of microbial metabolites, and potential therapeutic strategies targeting the microbiota. Understanding the role of gut microbiota in IBD pathogenesis could pave the way for novel diagnostic and therapeutic approaches.