高血圧ジャーナル: オープンアクセス

The Relationship between Micro Albuminuria and Plasma Homocysteine Level in Chinese Patients with Hypertension

Abstract

Wenlin MA, Ruhui LIU, Lin LI, Weiqi SHI, Liang DENG, Yan JIN and Ming LUO

Objective: To explore the relationship between plasma homocysteine (Hcy) and micro albuminuria in Chinese patients with hypertension.

Methods: 150 Chinese patients with hypertension were enrolled from October 2012 to April 2013 in Zhabei Central Hospital and Tongji hospital in Shanghai. Plasma level of Hcy, micro albuminuria, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein and fasting blood-glucose were measured, meanwhile possible related risk factors such as smoking, alcohol drinking were assessed. The enrolled patients were divided into two groups according to the plasma level of Hcy: hyperhomocysteinemia (Hcy) group (Hcy>15 μmol/L, male 41 cases, female 39 cases) and non- Hcy group (Hcy ≤ 15 μmol/L, male 32 cases, female 38 cases).

Results: The level of microalbuminuria was increased with the level of plasma Hcy .Microalbuminuria were higher in Hcy group (30.34 ± 8.85 mg/L) than in non- Hcy group (16.65 ± 3.28 mg/L, P<0.05); 2.Correlation analysis showed that the levels of plasma Hcy related positively with micro albuminuria (r=0.946, P<0.01). There were no significant correlation between Hcy and total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, fasting blood glucose (P>0.05).

Conclusion: Hcy is associated with a higher incidence of microalbuminuria in patients with hypertension.