統合腫瘍学ジャーナル

The Association between mrna Expression Levels of Ephx1 and Prognosis of Acute Myeloid Leukemia

Abstract

ChongMei Huang, Hui Cheng, XiaoQian Xu, XianMin Song, Li Chen and JianMin Yang

The human epoxide hydrolase 1 (EPHX1) is a metabolism gene, which is responsible for the first phase of the xenobiotic metabolism. The product, microsomal epoxide hydrolase (mHE), plays an important role in the detoxification of carcinogenic polycyclic aromatic hydrocarbons. Many reports also have studied the correlation between EPHX1 gene polymorphisms and development and generation of cancers. However, few of studies on EPHX1 participating in chemotherapeutics metabolism were reported. The purpose of the present study was to evaluate the prognostic significance of the EPHX1 gene expression in acute myeloid leukemia (AML). Using real time-quantitative polymerase chain reaction (RT-qPCR), mRNA expression levels of EPHX1 gene was measured in bone marrow samples of newly diagnosed AML patients (n=46) and control group (n=12) without tumors. The levels expression of EPHX1 had a significant association with the treatment response and prognosis of AML patients. Additionally, the EPHX1 expression levels can aid for an improved understanding of the multidrug resistant mechanism in AML.