核医学と放射線治療

Synthesis and Characterization of New Schiff Base Transition Metal Complexes Derived from Drug Together with Biological Potential Study

Abstract

Amina Mumtaz, Tariq Mahmud, Elsegood MR and Weaver GW

Purpose: In the quest for novel treatment against safe life form, the alteration of existing medication by mix to a metal focus has picked up consideration as of late. Thus, metal-based drug is seen as promising alternatives for possible replacement for some of the current drugs. So, we synthesized Schiff base metal complexes in this regard. Materials and Methods: A series of transition metal(II) complexes of new Schiff base were synthesized by the condensation of sulphadizine and 2-carboxybenzaldehyde in ethanol. Results: The Schiff base and transition metal complexes were characterized by using different instrumental techniques like microanalysis, thermogravimetric analysis and spectroscopy. The synthesized ligand and metal complexes were subjected to antibacterial studies. The studies showed the enhance activity of metal complexes against one or more species as compared to the uncomplexed ligand. Conclusions: The data showed that transition metal complexes have significant improved antibacterial activity than parent drug.