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Synthesis and Antimicrobial Activity of Azetidinone and Thiazolidinone Derivatives from Azolylindolyl Schiff's Bases

Abstract

P Siva Sankar, K Divya, A Padmaja and V Padmavathi

A new class of azolyl indolyl thiazolidinones and azetidinones were prepared from azolyl indolyl Schiff’s bases on reaction with thioglycolic acid and chloroacetyl chloride, respectively under ultrasonication at a frequency of 46 KHz. The chloro substituted thiazolyl indolyl azetidinone (12c) and imidazolyl indolyl azetidinone (13c) are prominent antibacterial agents against B. subtilis whereas 13c is the prominent antifungal agent against A. niger.

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