法医学研究ジャーナル

SOX Transcription Factors Control Cervical Cancer Development: Uncovering Therapeutic Strategies and Signaling Networks

Abstract

Gerald Devault

Cervical disease is the fourth normal gynaecologic malignant growth and is considered as second driving reason for death among ladies. Different procedures are applied in therapy of cervical malignant growth including radiotherapy, chemotherapy and medical procedure. Be that as it may, cervical disease cells show forceful conduct in cutting edge stages, requiring novel methodologies in their disposal. Then again, SOX proteins are record factors equipped for directing different sub-atomic pathways and their demeanour shifts during embryogenesis, infection improvement and carcinogenesis. In the current audit, our point is to uncover job of SOX record factors in cervical disease. SOX record factors play like a blade that cuts both ways in malignant growth. For example, SOX9 has both growth silencer and cancer advancing job in cervical disease. Hence, definite job of each SOX individual in cervical malignant growth has been examined to coordinate further analyses for uncovering different capabilities. SOX proteins can manage multiplication and metastasis of cervical malignant growth cells. Moreover, reaction of cervical malignant growth cells to chemotherapy and radiotherapy is firmly controlled by SOX record factors. Different downstream focuses of SOX proteins, for example, Wnt flagging, EMT and Hedgehog have been recognized. Furthermore, upstream arbiters, for example, microRNAs, lncRNAs and circRNAs can manage SOX articulation in cervical malignant growth.