免疫生物学ジャーナル

Role of Hypoxia and HIF Signaling in Immunometabolism

Abstract

Shizhang Reicher

Immunometabolism is a burgeoning field that explores the intricate connections between cellular metabolism and immune responses. Hypoxia- Inducible Factor (HIF) signaling pathways play a pivotal role in orchestrating the metabolic changes that underlie immune cell function. In this article, we delve into the fascinating interplay between hypoxia, HIFs and immunometabolism. We discuss how hypoxia influences immune cell metabolism and how HIFs act as key regulators of this process. Furthermore, we examine the implications of dysregulated HIF signaling in immune-related disorders and explore potential therapeutic avenues. Understanding the role of hypoxia and HIF signaling in immunometabolism is crucial for advancing our knowledge of immune system function and developing novel treatments for immune-mediated diseases.