核医学と放射線治療

Radiation Therapy in Optic Gliomas: A Case Report and a Review of Literature

Abstract

Dahlia F, Elisabetta P, Barbara T, Gianluca I, Ebtesam H, Sara T, Grazia T and Riccardo S

To assess the role of Radiation Therapy (RT), in the treatment of optic glioma analyzing 11 retrospective trials during the latest twenty-five years.

In a 25-year-old woman, referred to our centre because of right optic glioma, fractionated stereotactic radiation therapy (FSRT) was the treatment of choice using a commercial linear accelerator Elekta Synergy beam modulator with an integrated Cone Beam Computed Tomography (CBCT) system. In order to evaluate volumetric changes of the right optic nerve lesion a co-registration of pre-RT Magnetic Resonance Imaging (MRI) and CT planning scan was performed and compared with the co-registration of CT planning scan and MRI performed 3 years after the end of the treatment. A noticeable shrinkage in Clinical Target Volume was found and the patient experienced a complete recovery of the right eye visual deficit.

Successful Progression Free Survival and Overall Survival at 10 years can be obtained using a dose between 52 and 60 Gy. FSRT is advantageous compared to conventional RT because of sparing of normal tissues within the high dose volume. Modern linear accelerators with an integrated Cone Beam system improve treatment set-up and dose delivery