医療微生物学と診断

Preparation of the Silicone-Modified Antimicrobial Polyethylene Endotracheal Tube (PE ETT)

Abstract

Xuhong J, Bin LV, Xinmin W and Qianhong S

Polyethylene endotracheal tube (PE ETT) antimicrobial coating has been proved to be a more effective method to prevent endoluminal biofilm formation. A transparent silicone-modified antimicrobial PE ETT was obtained by coating SiO2/KH570/MTES/Ag-SiO2 solution prepared by chemical mixing Ag-SiO2 and SiO2/KH570/MTES solution by means of dip-coating method, followed by drying. All the films were characterized by various techniques including Pencil Hardness Tester, IR, SEM, UV-vis, and ICP-MS. The results indicated that the TEOS/KH570/MTES/Ag-SiO2 (15:6:1:0.6~1.0) films, which exhibit the simple solution-processable film formation on PE ETT, show homogeneous morphology, and have the high transmittance of above 87%, high hardness of 5H, strong adhesion. Furthermore, the silicone-modified antimicrobial PE ETTs show excellent antimicrobial property with the sterilization rate up to 93.5%, it demonstrates that the antimicrobial films have excellent biocompatibility and potent antimicrobial activity against protein adhesion. Pyrogen test, hemolysis test and oral mucous irritation test results are fit for biosecurity use requirement for biological materials. So, silicone-modified antimicrobial PE ETT is hoped to be used in the field of medical materials and can be used as an efficient and economical method to extend the service life of the PE ETT.