美容学とトリコロジーのジャーナル

Polydatin and Atopic Dermatitis in Adults: Clinical Study

Abstract

Giuseppe Maria Izzo and Giovanni Suffritti

Objective: Verify the clinical efficacy of polydatin applied topically, associated or not with systemic administration of polydatin, on the cutaneous manifestations of moderate to severe atopic dermatitis and check patients' adherence to treatment through a simple evaluation sheet filled in by the investigator and by the patient at baseline and after 7, 14, 30 and 60 days.
Methods: Included 128 patients with moderate to severe atopic dermatitis, with lesions on face, on trunk and/or limbs. In 64 of them (age: mean+SEM 35.73+1.03 years - range 18 to 52 years, 33 males and 31 females) a topical cream and a cleanser, both polydatin based were prescribed, while in 64 others (age: mean+SEM 35.75+1.37 years - range 16 to 58 years, 34 males and 30 females) an oral supplement containing 40 mg polydatin was added.
Results: An important reduction of variable degree of lesions and subjective symptoms of atopic dermatitis, such as itching, erythema, xerosis, lichenification of the skin and eczematous lesions has been observed.
Conclusion: The use of topical cream and cleanser associated with oral administration of polydatin tablets restores the function of the skin barrier, counteracts the action of irritants or allergens, reduces the local inflammatory response, and eliminates the itching and scratching.